发明名称 |
METHODS FOR REPAIRING TISSUE DAMAGE USING PROTEASE-RESISTANT MUTANTS OF STROMAL CELL DERIVED FACTOR-1 |
摘要 |
<p>The present invention features methods for treating or ameliorating tissue damage using intravenous administration of compositions that include stromal cell derived factor-1 (SDF-1) peptides or mutant SDF-1 peptides that have been mutated to make them resistant to protease digestion, but which retain chemoattractant activity. Systemic delivery, and specifically intravenous (“IV”) delivery, of SDF-1 and protease resistant SDF-1 mutants is very effective for the treatment of tissue damage.</p> |
申请公布号 |
EP2717894(A1) |
申请公布日期 |
2014.04.16 |
申请号 |
EP20120796309 |
申请日期 |
2012.06.06 |
申请人 |
MESOBLAST INTERNATIONAL SARL |
发明人 |
SANDRASAGRA, ANTHONY;WU, WEITAO |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|