发明名称 |
RABIES VIRUS LIKE PARTICLE PRODUCTION IN PLANTS |
摘要 |
<p>A method of producing a virus like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a native rabies virus structural protein. The nucleotide sequence may further comprise one or more than one amplification element. Optionally, a second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprising a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a matrix protein, for example but not limited to a rabies matrix protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.</p> |
申请公布号 |
EP2718428(A1) |
申请公布日期 |
2014.04.16 |
申请号 |
EP20120801020 |
申请日期 |
2012.06.13 |
申请人 |
MEDICAGO INC. |
发明人 |
D'AOUST, MARC-ANDRE;LAVOIE, PIERRE-OLIVIER;VEZINA, LOUIS-PHILIPPE;COUTURE, MANON |
分类号 |
A61K39/00;A61K39/205;A61K39/295;A61P31/16;A61P37/04;C07K14/005;C07K14/11;C12N7/00;C12N15/82;C12P17/06 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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