发明名称 |
HETEROCYCLIC PIM-KINASE INHIBITORS |
摘要 |
<p>New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer.</p> |
申请公布号 |
EP2344473(B1) |
申请公布日期 |
2014.04.16 |
申请号 |
EP20090782379 |
申请日期 |
2009.08.31 |
申请人 |
NOVARTIS AG |
发明人 |
BURGER, MATTHEW;LAN, JIONG |
分类号 |
C07D401/12;A61K31/4709;A61K31/517;A61P35/00 |
主分类号 |
C07D401/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|