COMBINATION DRUG COMPRISING GEMIGLIPTIN AND METFORMIN AND METHOD FOR THE PREPARATION THEREOF

摘要

The present invention relates to a combination drug comprising gemigliptin and metformin as active ingredients and a method for preparing the same. A bilayer pharmaceutical formulation consisting of a first layer comprising metformin and a second layer comprising gemigliptin according to the present invention relieves side effects of an existing single formulation and has a superior effect on prevention and treatment of diabetes and complex diseases thereof. In addition, the formulation comprises gemigliptin and metformin in a separated form so as to maintain inherent dissolution rates of gemigliptin and metformin and improve patient compliance. [Reference numerals] (AA) Dissolution rate(%); (BB) Time(minute); (CC) Gemigliptin 50 mg; (DD) Comparative example 1; (EE) Example 1; (FF) Example 2