发明名称 |
Preparation of taxanes from 9-dihydro-13-acetylbaccation III |
摘要 |
A new process for preparing a compound of Formula V, wherein P is a hydroxy protecting group and R is acetyl, said process including the steps of: i) selectively deacetylating the 10-hydroxy group of 9-dihydro-13-acetylbaccatin III with N,N-dimethylethylenediamine to produce 9-dihydro-10-deacetyl-13-acetyl-baccatin III; ii) concomitantly protecting 7-hydroxy and 10-hydroxy groups of the reaction product of step i); and iii) oxidizing the 9-hydroxy group of the reaction product of step ii) with an oxidizing agent to produce the compound of formula V. |
申请公布号 |
US8697894(B2) |
申请公布日期 |
2014.04.15 |
申请号 |
US201113031378 |
申请日期 |
2011.02.21 |
申请人 |
CARON GAETAN;LOURDUSAMY METTILDA;ACCORD HEALTHCARE LTD. |
发明人 |
CARON GAETAN;LOURDUSAMY METTILDA |
分类号 |
C07D305/00;C07D407/00;C07D493/00 |
主分类号 |
C07D305/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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