发明名称 |
Protein agent for diabetes treatment andβcell imaging |
摘要 |
The 30 amino acid peptide GLP-1 has been integrated into the stable host protein human calbindin D9k. The fusion protein binds to GLP-1R. The fusion protein agents can be useful for both diabetes treatment and GLP-1R receptor targeting MR imaging. The fusion protein comprises a first peptide that selectively binds to a site of a target cell and linked to a second peptide, where the fusion protein is more stable than the first peptide alone and may further comprise a detectable label. The first peptide of the fusion protein may be glucagon-like peptide-1 (GLP-1), glucagon-like peptide-1 (GLP-1)(7-36), or glucagon-like peptide-1 (GLP-1) (9-36), or a conservative variant thereof. |
申请公布号 |
US8697648(B2) |
申请公布日期 |
2014.04.15 |
申请号 |
US201013503194 |
申请日期 |
2010.10.20 |
申请人 |
LIU ZHI-REN;YANG JIE;XU BING;ZHOU WANGDA;XUE SHENGHUI;GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. |
发明人 |
LIU ZHI-REN;YANG JIE;XU BING;ZHOU WANGDA;XUE SHENGHUI |
分类号 |
A61K38/26;A61K38/00;A61K47/48;A61K49/08;C07K14/605;C07K19/00 |
主分类号 |
A61K38/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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