POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE

摘要

THE INVENTION RELATES TO NEW CRYSTALLINE MODIFICATIONS OF THE HYDROCHLORIDE OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYL-BENZOFURAN-5-YL)-PIPERIZINE, CRYSTALLINE MODIFICATION OF THE DIHYDROCHLORIDE OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYL-BENZOFURAN-5-YL)-PIPERIZINE AND AMORPHOUS 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYL-BENZOFURAN-5-YL)-PIPERIZINE HYDROCHLORIDE WHICH ARE SUITABLE IN PARTICULAR FOR THE PREPARATION OF SOLID MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF DEPRESSIVE DISORDERS, ANXIETY DISORDERS, BIPOLAR DISORDERS, MANIA, DEMENTIA, SUBSTANCE-RELATED DISORDERS, SEXUAL DYSFUNCTIONS, EATING DISORDERS, OBESITY, FIBROMYALGIA, SLEEPING DISORDERS, PSYCHIATRIC DISORDERS, CEREBRAL INFARCT, TENSION, FOR THE THERAPY OF SIDE-EFFECTS IN THE TREATMENT OF HYPERTENSION, CEREBRAL DISORDERS, CHRONIC PAIN, ACROMEGALY, HYPOGONADISM, SECONDARY AMENORRHEA, PREMENSTRUAL SYNDROME AND UNDESIRED PUERPERAL LACTATION.