| 发明名称 |
ANGIOPOIETIN-LIKE 3(ANGPTL3) IRNA COMPOSTIONS AND METHODS OF USE THEREOF |
| 摘要 |
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of ANGPTL3 and methods of treating subjects having a disorder of lipid metabolism, such as hyperlipidemia or hypertriglyceridemia, using such dsRNA compositions. |
| 申请公布号 |
KR20140044870(A) |
申请公布日期 |
2014.04.15 |
| 申请号 |
KR20147001670 |
申请日期 |
2012.06.20 |
| 申请人 |
ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
BETTENCOURT BRIAN;QUERBES WILLIAM;FITZGERALD KEVIN;FRANK KAMENETSKY MARIA;MILSTEIN STUART;SHULGA MORSKAYA SVETLANA |
| 分类号 |
C12N15/113;A61K48/00;C07H21/04 |
主分类号 |
C12N15/113 |
| 代理机构 |
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