摘要 |
The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention. |
申请人 |
ANAND NEEL KUMAR;BLAZEY CHARLES M.;BOWLES OWEN JOSEPH;BUSSENIUS JOERG;COSTANZO SIMONA;CURTIS JEFFRY KIMO;DUBENKO LARISA;KENNEDY ABIGAIL R.;DEFINA STEVEN CHARLES;KIM ANGIE I.;MANALO JEAN-CLAIRE L.;PETO CSABA J.;RICE KENNETH D.;TSANG TSZE H.;JOSHI ANAGHA ABHIJIT;EXELIXIS, INC. |
发明人 |
ANAND NEEL KUMAR;BLAZEY CHARLES M.;BOWLES OWEN JOSEPH;BUSSENIUS JOERG;COSTANZO SIMONA;CURTIS JEFFRY KIMO;DUBENKO LARISA;KENNEDY ABIGAIL R.;DEFINA STEVEN CHARLES;KIM ANGIE I.;MANALO JEAN-CLAIRE L.;PETO CSABA J.;RICE KENNETH D.;TSANG TSZE H.;JOSHI ANAGHA ABHIJIT |