发明名称 |
Polymerkonjugater af K-252A og derivater heraf |
摘要 |
The present invention relates to novel polymer conjugates of K-252a and derivatives thereof and to their use for the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of kinase-associated pathologies. In particular, the present invention relates to the prevention, alleviation and treatment of HMGB1-associated pathologies. The invention relates to the use of the novel polymer conjugates of K-252a and derivatives thereof in the preparation of a pharmaceutical composition useful for the prevention, alleviation and treatment of a) neurological disorders, neuropathies and neurodegenerative disorders of the central and peripheral nervous system; b) dermal pathologies, in particular dermal pathologies associated with an excessive keratinocyte proliferation, in particular psoriasis; and c) NGF-related pain. More specifically, the present invention relates to a polymer conjugate of K-252a and derivatives thereof, wherein the polymer is polyethylene glycol or methoxy-polyethylene glycol formula (I). |
申请公布号 |
DK1919979(T3) |
申请公布日期 |
2014.04.14 |
申请号 |
DK20060777076T |
申请日期 |
2006.08.25 |
申请人 |
CREABILIS THERAPEUTICS S.P.A. |
发明人 |
TRAVERSA, SILVIO;BAGNOD, RAFFAELLA;BARONE, DOMENICO;BERTARIONE RAVA ROSSA, LUISA;FUMERO, SILVANO;MAINERO, VALENTINA;ODERDA, CECILIA;PINCELLI, CARLO;LORENZETTO, CHIARA;MARCONI, ALESSANDRA;BECCARIA, LUCA |
分类号 |
A61K31/765;A61K47/48;A61P17/00;A61P19/00;A61P25/00;A61P35/00;C08G61/12;C08G73/06 |
主分类号 |
A61K31/765 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|