发明名称 |
NONINVASIVE DETECTION OF FETAL GENETIC ABNORMALITY |
摘要 |
The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc. |
申请公布号 |
US2014099642(A1) |
申请公布日期 |
2014.04.10 |
申请号 |
US201113641080 |
申请日期 |
2011.06.29 |
申请人 |
JIANG FUMAN;CHEN HUIFEI;CHAI XIANGHUA;YUAN YUYING;ZHANG XIUQING;CHEN FANG;BGI SHENZHEN CO., LIMITED |
发明人 |
JIANG FUMAN;CHEN HUIFEI;CHAI XIANGHUA;YUAN YUYING;ZHANG XIUQING;CHEN FANG |
分类号 |
G06F19/18 |
主分类号 |
G06F19/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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