Method for synthesizing (S)-bepotastine and novel intermidate thereof

摘要

The present invention provides a method for synthesizing (S)-bepostatine comprising: a) a step for obtaining (S)-bepostatine (-)-bornyl ester represented by the following chemical formula 4 by reacting (RS)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine racemic body with (-)-bornyl ester compound represented by the following chemical formula 3 in organic solvent under presence of base; b) a step for obtaining organic acid salts represented by the following chemical formula 5 by reacting the compound represented by the chemical formula 4 with organic acid in organic solvent; c) a step for liberating the compound represented by the chemical formula 4 by reacting the obtained organic acid salts represented by the chemical formula 5 under presence of base; and d) a step for hydrolyzing the liberated compound represented by the chemical formula 4 under presence of base.