| 摘要 |
PROBLEM TO BE SOLVED: To provide pharmaceutical compositions for oral administration, in particular administration as an oral delivery system to be swallowed directly or capable of disintegration in the oral cavity, to control a serum phosphate level in patients with chronic renal insufficiency, the composition comprising iron oxy-hydroxide in high loading as a phosphate adsorber.SOLUTION: The iron oxy-hydroxide-containing pharmaceutical composition comprises one or more carbohydrates and/or humic acid, preferably a carbohydrate such as a mono- di- or polysaccharide, preferably saccharose (sucrose), starch, agarose, dextran, dextrin, cellulose and derivatives of each of these. The composition further comprises one or more flavoring agents, sweeteners, taste-enhancing agents, and/or coloring agents In addition, the composition further comprises one or more excipients, superdisintegrants, glidants, antioxidants. |
