COMPOSITIONS AND METHODS TO TREAT DISEASE CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for preventing and/or treating diseases caused by abnormal cellular proliferation, abnormal angiogenesis or a combination thereof.SOLUTION: Described herein are compositions and methods for preventing and/or treating diseases caused by abnormal angiogenesis employing a series of benzo[c]chromen-6-one derivatives, demonstrating enhanced anti-proliferative effects against human endothelial cells for the treatment of a variety of diseases, including, but not limited to, cancer.