发明名称 |
PROCESS FOR PREPARATION OF SUCCINYLCHOLINE CHLORIDE |
摘要 |
The present invention relates to a process for the preparation of succinylcholine chloride, a pharmaceutically active compound used as skeletal muscle relaxant which comprises condensing succinic anhydride with N,N-diemthylaminoethanol using a catalyst in presence of a solvent to form bis[2-(dimethylamino)ethyl]succinate; in situ purifying the bis[2-(dimethylamino)ethyl]succinate using a base; reacting pure bis[2-(dimethylamino)ethyl]succinate with methyl chloride gas using an alcohol; and purifying the obtained crude succinylcholine chloride using water and alcohol. |
申请公布号 |
US2014100385(A1) |
申请公布日期 |
2014.04.10 |
申请号 |
US201313771872 |
申请日期 |
2013.02.20 |
申请人 |
SEQUENT SCIENTIFIC LIMITED |
发明人 |
MANJATHURU MAHALINGA;MAYEKAR ANIL NARAYAN;VASUDEVA PEJAKALA KAKRANNAYA;ARULMOLI THANGAVEL;DAS GAUTAM KUMAR |
分类号 |
C07C213/06 |
主分类号 |
C07C213/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|