发明名称 |
PROCESS FOR PREPARING STABLE ANTIBODY MAYTANSINOID CONJUGATES |
摘要 |
<p>The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved stability comprising performing the modification reaction at a high pH. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent in a solution having a pH of 7.1 to 9 to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto.</p> |
申请公布号 |
WO2014055842(A1) |
申请公布日期 |
2014.04.10 |
申请号 |
WO2013US63415 |
申请日期 |
2013.10.04 |
申请人 |
IMMUNOGEN, INC. |
发明人 |
LI, XINFANG;WORFUL, JARED |
分类号 |
C07K16/00;A61K39/00;A61P35/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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