| 摘要 |
The present invention provides an ex vivo method for aiding the diagnosis of Alzheimer's disease in a patient comprising:(i) determining the number of alleles of ApoE4 in the patient's genome;(ii)determining the combined expression level of at least threeplatelet proteins in a platelet sample from the patient; and(iii)comparing the resulting value of step (ii) to a control value, wherein the at least three platelet proteins include at least one isoform of alpha-tropomyosin containing exon 1a and at least two platelet proteins selected frommonoamine oxidase-B, coagulation factor XIIIa,wild-type GSTO-1 or mutant GSTO-1,wherein a result higher than the control value is indicative of Alzheimer's disease. The invention also provides a solid support comprisingoneormoreligandsof at least one isoform of alpha-tropomyosin containing exon 1a, and one or more ligands of at least two platelet proteins selectedfrommonoamineoxidase-B, coagulationfactor XIIIa,wild-type GSTO-1proteinand/ormutant GSTO-1 protein immobilised thereon. |
