| 摘要 |
[Problem] To provide an industrially preferable method for manufacturing an isothiazole compound, particularly 3,4-dichloro-5-cyanoisothiazole. For example, to provide a safer industrial manufacturing method by avoiding simultaneous use of chlorine and an aprotic polar solvent such as N,N-dimethylformamide. Furthermore, to provide a manufacturing method that is economically preferable because aprotic polar solvents, which have a high possibility of becoming a portion of waste products, are not used. [Solution] A method for manufacturing an isothiazole compound expressed by general formula (3) (where R represents a cyano group or the like, and X represents a chlorine atom or the like), characterized by heating sulfur and a nitrile compound expressed by general formula (1) (where R is defined as above), and then reacting the nitrile compound expressed by general formula (1) with sulfur and a halogen expressed by general formula (2) (where X is defined as above). |
