发明名称 METHODS FOR TREATMENT OF ALPORT SYNDROME
摘要 Provided herein are methods for the treatment of Alport Syndrome, using modified oligonucleotides targeted to miR-21. In certain embodiments, a modified oligonucleotide targeted to miR-21 improves kidney function and/or reduces fibrosis in subjects having Alport Syndrome. In certain embodiments, administration of a modified oligonucleotide targeted to miR-21 delays the onset of end-stage renal disease in a subject having Alport Syndrome. In certain embodiments, a modified oligonucleotide targeted to miR-21 delays the need for dialysis or kidney transplant in a subject having Alport Syndrome.
申请公布号 US2014100263(A1) 申请公布日期 2014.04.10
申请号 US201314048827 申请日期 2013.10.08
申请人 REGULUS THERAPEUTICS INC. 发明人 DUFFIELD JEREMY;BHAT BALKRISHEN;MACKENNA DEIDRE
分类号 C12N15/113;A61K31/7088;A61K45/06 主分类号 C12N15/113
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