发明名称 |
METHODS FOR TREATMENT OF ALPORT SYNDROME |
摘要 |
Provided herein are methods for the treatment of Alport Syndrome, using modified oligonucleotides targeted to miR-21. In certain embodiments, a modified oligonucleotide targeted to miR-21 improves kidney function and/or reduces fibrosis in subjects having Alport Syndrome. In certain embodiments, administration of a modified oligonucleotide targeted to miR-21 delays the onset of end-stage renal disease in a subject having Alport Syndrome. In certain embodiments, a modified oligonucleotide targeted to miR-21 delays the need for dialysis or kidney transplant in a subject having Alport Syndrome. |
申请公布号 |
US2014100263(A1) |
申请公布日期 |
2014.04.10 |
申请号 |
US201314048827 |
申请日期 |
2013.10.08 |
申请人 |
REGULUS THERAPEUTICS INC. |
发明人 |
DUFFIELD JEREMY;BHAT BALKRISHEN;MACKENNA DEIDRE |
分类号 |
C12N15/113;A61K31/7088;A61K45/06 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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