METHODS FOR DIAGNOSING AND PROGNOSING PLACENTAL DYSFUNCTION AND PRE-ECLAMPSIA

摘要

Provided herein are methods for determining placental dysfunction in a female suspected of having placental dysfunction or preclampsia by assessing the expression of P1GF in a biological sample of a female patient who is less than 35 weeks pregnant. Also described herein are methods for assigning a prognosis for a future complication associated with pregnancy in a female suspected of having placental dysfunction who is less than 35 weeks pregnant. The invention further relates to methods of managing and mitigating risks of pregnant females suspected of having placental dysfunction or pre-eclampsia to monitor the health and well-being of the baby and mother. Said methods can be used at the time of initial assessment for suspected placental dysfunction or pre-clampsia to identify a group of pregnant females with a placental dysfunction or pre-eclampsia, and to determine the potential to develop any complications of placental dysfunction or pre-eclampsia. Therefore, methods not only are able to provide very useful prognostic information for patients but also can help clinicians to select a candidate pregnant female likely to benefit from early and aggressive pre-eclampsia therapy.