| 摘要 |
<p>Disclosed is a pharmaceutical composition for oral administration, which comprises a controlled release part, which comprises tamsulosin or a pharmaceutically acceptable salt thereof, and a rapid release part, which comprises solifenacin or a pharmaceutical acceptable salt thereof and a hydrophilic substance. In the pharmaceutical composition, the rates of dissolution of the medicaments (particularly the solifenacin contained in the rapid release part) are unchanged from the conventional pharmaceutical preparations, and the maximum rates of disolution of the individual medicaments (particularly the solifenacin contained in the rapid release part) are 90% or more. Therefore, the pharmaceutical composition is a single preparation (a combined preparation) having an equivalent level of bioavailability to those of the conventional pharmaceutical preparations.</p> |
