THE METHOD FOR SCREENING KNOCK-OUT TARGETS IN 3-HYDROXYPROPIONATE PRODUCING YEAST KLUYVEROMYCES MARXIANUS, USING GENOME-SCALE METABOLIC NETWORK MODEL

摘要

An embodiment relates to a metabolic network model for analyzing metabolic characteristics of Kluyveromyces marxianus microorganisms for producing 3HP and to metabolic characteristic analysis of Kluyveromyces marxianus using the same. More specifically, the present invention relates to building metabolic network model of the Kluyveromyces marxianus using gene-protein-biochemistry reaction relationship, to analysis of metabolic characteristics of metabolic flux using the model, and to a method for predicting a novel metabolic path which enhances production capacity of the 3HP using simulation based on metabolic flux. The method of an embodiment can efficiently predict cell growth speed and production of microorganisms, save time and costs for optimizing the novel path, and provide variant microorganisms which can produce specific metabolites with high efficiency.