HETERODIMERIC PROTEIN COMPOSITION

摘要

The present invention can provide: a heterodimeric protein composition which is a protein comprising a first polypeptide containing an immunoglobulin heavy-chain constant region and a second polypeptide containing a CL-Fc fragment that is a fusion of an immunoglobulin light-chain constant region (CL) and an Fc region, wherein a Cys residue involved in the disulfide bond between the CL region and a CH1 region is deleted or substituted; a method for purifying the protein composition; a method for producing the protein composition; DNA encoding the protein composition; and a vector.