发明名称 |
HIGH POTENCY SIRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
摘要 |
The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs. |
申请公布号 |
US2014099715(A1) |
申请公布日期 |
2014.04.10 |
申请号 |
US201313972072 |
申请日期 |
2013.08.21 |
申请人 |
APPLIED BIOSYSTEMS, LLC |
发明人 |
BROWN DAVID;FORD LANCE P.;PALLOTTA VINCE;PASLOSKE BRITTAN L.;JARVIS RICHARD A. |
分类号 |
C12N15/113;C12N5/02;C12N15/11 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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