COMPOSITION FOR HYPERTHERMIA COMPRISING SENSITIZATION MATERIAL

摘要

The present invention relates to an in vivo heat-dissipating composition comprising a sensitization material selected from the group consisting of (i) magnetic nanoparticles and (ii) chemodrugs, biodrugs and radioisotope; and to a composition for hyperthermia, comprising the vivo heat-dissipating composition as an active ingredient. The compositions of the present invention may have heat-dissipating effects caused by both external stimuli and magnetic nanoparticles, and therefore, may exhibit superior synergistic effects in the apoptosis of target cells, in particular cancer cells. In particular, if the compositions of the present invention are made into a composite of 'magnetic nanoparticle-sensitization material', both a thermal effect by a single stimulus which is a high frequency magnetic field and a sensitization effect by a sensitization material are achieved at the same time. Thus, the compositions of the present invention can be used as effective compositions for treatment.