COMPUTATIONAL METHODS FOR ANALYSIS AND MOLECULAR DESIGN OF ANTIBODIES, ANTIBODY HUMANIZATION, AND EPITOPE MAPPING COUPLED TO A USER-INTERACTIVE WEB BROWSER WITH EMBEDDED THREE- DIMENSIONAL RENDERING

摘要

This disclosure relates in general to the field of antibody modeling and analysis. The disclosed subject matter describes a single online workspace to model and analyze antibody sequences or structures. Modeling and analysis may be performed by employing a number of features including, but not limited to, sequence analysis, structure analysis, antibody modeling, packing, antibody humanization, mutations, design, loop modeling, protein-protein docking, and scoring.