THE WATER-INSOLUBLE ITRACONAZOLE COVERED WITH AMORPHOUS SURFACTANT AND METHOD FOR PREPARING THE SAME

摘要

The present invention relates to an amorphous itraconazole covered with a surfactant and a preparation method thereof. The amorphous itraconazole covered with a surfactant according to an embodiment in the present invention comprises: 100 parts by weight of itraconazole; and 10-200 parts by weight of a surfactant with respect to the weight of the itraconazole, wherein the surfactant has two or more alkyl chains adhering to a hydrophilic part thereof. The surfactant adheres to the itraconazole while surrounding the outside of the itraconazole in an amorphous form, so that the itraconazole is dissolved in an emulsion type in water. The itraconazole to which the surfactant adheres has an average diameter of 0.5-30 micrometers, and the average size range of the itraconazole is within±200% with respect to the diameter of the itraconazole. [Reference numerals] (AA) Hydrophilic part of a surfactant; (BB) Slightly soluble substance; (CC) Surfactant; (DD) Alkyl chain part of the surfactant