METHODS OF QUANTITATING HEAVY AND LIGHT CHAIN POLYPEPTIDE PAIRS
摘要
<p>Provided is a method of quantitatively determining the ability of individual IgG heavy chains to selectively pair with a particular IgG light chain when the heavy chains and two unique light chains are co-expressed. The method provides results with reasonable throughput and is robust and accurate. The co-expressed heavy and light chains do not need to be isolated and purified which enables more efficient screening.</p>
申请公布号
CA2886422(A1)
申请公布日期
2014.04.10
申请号
CA20132886422
申请日期
2013.10.03
申请人
ZYMEWORKS INC.;NATIONAL RESEARCH COUNCIL CANADA (NRC)
发明人
BAARDSNES, JASON;O'CONNOR-MCCOURT, MAUREEN;OHRN, ANDERS;CORPER, ADAM LOUIS;NG, GORDON YIU KON;SAMIOTAKIS, ANTONIOS;CHOU, YANG-CHIEH