发明名称 |
GDF-8 INHIBITORS |
摘要 |
Described are GCF-8 inhibitors of the formula (I), and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R5, R6, X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue. |
申请公布号 |
CA2887203(A1) |
申请公布日期 |
2014.04.10 |
申请号 |
CA20132887203 |
申请日期 |
2013.10.04 |
申请人 |
RIGEL PHARMACEUTICALS, INC. |
发明人 |
BHAMIDIPATI, SOMASEKHAR;GELMAN, MARINA;DING, PINGYU;SINGH, RAJINDER;CLOUGH, JEFFREY;KINSELLA, TODD;PAYAN, DONALD |
分类号 |
C07D401/14;C07D213/26;C07D401/04;C07D413/04;C07D417/04;C07D417/14;C07D453/02;C07D487/04;C07D498/04 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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