| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to compound of formula (I) or its pharmaceutically acceptable salt, where A stands for -CHR-, where Rrepresents hydrogen, Calkyl, optionally substituted with substituent, selected from -OH, -OR, where Rrepresents Calkyl, -NH, -COOH and -CONH, Caryl-Calkyl, optionally substituted with 1-3 substituents, selected from-OH, -OP(=O)(OH), -OP(=O)(ONa)and Calkyl, 5-9-member heteroaryl- Calkyl, Ccycloalkyl-Calkyl, Caryl or Ccycloalkyl; G stands for -NR- or -O-, where Ris independently selected from Calkyl and Calkenyl; Rstands for -Ra-R; where Ra stands for Calkylene and Rrepresents naphthyl or 9-10-member bicyclic condensed heteroaryl, optionally substituted with substituent selected from -NHand halogen; Rrepresents -W-W-Rb-R, where Wrepresents -(CO)-; Wrepresents -O- or -NH-; Rb represents bond or Calkylene, optionally substituted with Calkyl; and Rrepresents Calkyl, Caryl, optionally substituted woth halogen, 5-6-member heteroaryl or Ccycloalkyl; and Rrepresents Calkyl; where "heteroaryl" represents monocyclic or bicyclic aromatic radical, where 1-3 ring atoms are heteroatoms, selected from nitrogen, oxygen and sulphur, and remaining ring atoms are carbon atoms and "bicyclic condensed" means ring, bound with another ring with formation of bicyclic structure, when atoms, common for both rings, are directly bound to each other. Invention also relates to particular compounds, method of treating or preventing disorder, modulated by Wnt-signaling pathway, agent, based on (I)formula compound, intermediate compound of formula (II), method of obtaining formula (I) compound.EFFECT: obtained are compounds, represented by formula (I), which possess useful biological properties.32 cl, 3 dwg, 2 tbl, 209 ex |
