发明名称 |
NON-PEPTIDE AGONISTS AND ANTAGONISTS OF ADRENOMEDULLIN AND GASTRIN RELEASING PEPTIDE |
摘要 |
This invention relates, e.g., to methods for inhibiting or stimulating an activity of an adrenomedullin (AM) or gastrin releasing peptide (GRP) peptide hormone, comprising contacting the peptide with a small molecule, non-peptide, modulatory agent of the invention. Complexes of these modulatory agents with other components, such as the peptides or blocking antibodies specific for the peptides, are also described, as are pharmaceutical compositions comprising the modulatory agents, and methods for using the modulatory agents to diagnose or treat patients. |
申请公布号 |
US2014100163(A1) |
申请公布日期 |
2014.04.10 |
申请号 |
US201314103605 |
申请日期 |
2013.12.11 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY. DEPARTMENT OF HEALTH AND HUMAN SERV;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV |
发明人 |
CUTTITTA FRANK;MARTINEZ ALFREDO |
分类号 |
A61K47/48;A61K31/192;A61K31/194;A61K31/197;A61K31/4196;A61K31/433;A61K31/439;A61K31/44;A61K31/445;A61K31/4453;A61K31/45;A61K31/52;A61K38/22;A61P3/10;A61P9/02;A61P9/08;A61P9/10;A61P35/00;G01N33/68;G01N33/74 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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