| 摘要 |
<p>A conformationally-constrained kinked peptide includes: a conformationally- constraining portion and a kinked portion linked to the conformationally-constraining portion that conformationally constrains the kinked portion, the kinked portion comprising an endosomal-disrupting peptide. The peptide can include a peptide sequence of one of SEQ ID NOs: 1, 5-38, or 40-69. The conformationally-constrained kinked portion can be a majority portion or minority of the peptide. The peptide can include one of Formulae 1-lC, wherein: CC-Peptide includes a peptide that conformationally constrains the ED-KP; Peptide independently includes natural, unnatural, essential or non-essential aromatic, aliphatic, or other amino acids having L or D configuration; ED- KP includes an endosomal-disrupting kinked peptide; Xaa, Xaa 1, and Xaa 2 are independently one or more natural or non-natural amino acids, essential amino acids, or non-essential amino acids, or derivatives of amino acids having L or D configuration; LI and L2 are independently linkers; and nl, n2, n3, and n4 are independently 0-50.</p> |
