发明名称 |
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF |
摘要 |
<p>It is intended to provide a compound represented by the formula (I):
wherein all the symbols are as defined in the description;
which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.</p> |
申请公布号 |
EP1932840(B1) |
申请公布日期 |
2014.04.09 |
申请号 |
EP20060811080 |
申请日期 |
2006.10.02 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
NAKAI, HISAO;YAMAMOTO, SHINGO;NAKATANI, SHINGO;HIROSAKI, TOMOMI |
分类号 |
C07D401/04;A61K31/4439;A61K45/00;A61P9/00;A61P11/00;A61P19/02;A61P19/08;A61P29/00;A61P43/00;C07D405/14;C07D413/04 |
主分类号 |
C07D401/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|