发明名称 |
RADIOACTIVE IODINE LABELED COMPOUND HAVING AFFINITY FOR AMYLOID |
摘要 |
It is intended to provide a compound that is effective as a diagnostic imaging probe that targets amyloid, and a diagnostic agent for Alzheimer's disease comprising the compound. Provided are a compound represented by the following formula (1), or salt thereof:
wherein R 1 is a radioactive halogen substituent, A 1 and A 2 independently represent CH or N, and a diagnostic agent for Alzheimer's disease, comprising the compound represented by the above formula or a salt thereof. The above compound and the above diagnostic agent for Alzheimer's disease transfer into brain after administration, and indicate good accumulation on amyloid deposited in the brain. |
申请公布号 |
EP2716641(A1) |
申请公布日期 |
2014.04.09 |
申请号 |
EP20120789191 |
申请日期 |
2012.05.18 |
申请人 |
NIHON MEDI-PHYSICS CO., LTD. |
发明人 |
OKUMURA, YUKI;MAYA, YOSHIFUMI;SHOYAMA, YOSHINARI;ONISHI, TAKAKO |
分类号 |
C07D471/04;A61K31/437;A61K51/00;A61K51/04;C07F7/22 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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