发明名称 |
Polynucleotides encoding novel PCSK9 variants |
摘要 |
The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. |
申请公布号 |
EP2639301(A3) |
申请公布日期 |
2014.04.09 |
申请号 |
EP20130153786 |
申请日期 |
2007.06.29 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
MINTIER, GABRIEL, A.;CHEN, JIAN;FEDER, JOHN, N.;PARKER, REX, A.;MIAO, BOWMAN |
分类号 |
C12N9/64;A61K38/00 |
主分类号 |
C12N9/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|