| 发明名称 |
USE OF HMG FRAGMENT AS ANTI-INFLAMMATORY AGENTS |
| 摘要 |
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade. |
| 申请公布号 |
CA2447576(C) |
申请公布日期 |
2014.04.08 |
| 申请号 |
CA20022447576 |
申请日期 |
2002.05.15 |
| 申请人 |
NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE;THE GENERAL HOSPITAL CORPORATION;UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
TRACEY, KEVIN J.;YANG, HUAN;WARREN, HOWLAND SHAW JR.;FINK, MITCHELL P. |
| 分类号 |
C07K16/18;C12N15/09;A61K38/00;A61K39/395;A61P1/02;A61P1/04;A61P3/04;A61P3/10;A61P5/14;A61P7/00;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P13/00;A61P13/08;A61P15/02;A61P17/16;A61P19/02;A61P21/04;A61P25/00;A61P25/04;A61P25/28;A61P27/02;A61P29/00;A61P31/04;A61P31/12;A61P31/16;A61P31/18;A61P31/20;A61P31/22;A61P33/06;A61P37/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K14/00;C07K14/435;C07K14/47;C07K16/00;C12N5/06;C12N5/10;C12N15/12;C12P21/06;C12Q1/02 |
主分类号 |
C07K16/18 |
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