发明名称 |
Organic-inorganic hybrid scaffolds with surface-immobilized nano-hydroxyapatite and preparation method thereof |
摘要 |
Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality. |
申请公布号 |
US8691882(B2) |
申请公布日期 |
2014.04.08 |
申请号 |
US20090635615 |
申请日期 |
2009.12.10 |
申请人 |
LEE SANG CHEON;CHANG JEONG HO;LEE JIN HYUNG;KIM KYUNG JA;KIM SUNG EUN;HWANG HO CHAN;KANG KE-WON;SEO SEOG-JIN;KIM JIN-YOUNG;KOREA INSTITUTE OF CERAMIC ENGINEERING & TECHNOLOGY |
发明人 |
LEE SANG CHEON;CHANG JEONG HO;LEE JIN HYUNG;KIM KYUNG JA;KIM SUNG EUN;HWANG HO CHAN;KANG KE-WON;SEO SEOG-JIN;KIM JIN-YOUNG |
分类号 |
C07K14/78;C08G63/06;C08J9/00 |
主分类号 |
C07K14/78 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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