| 发明名称 |
DERIVADOS DE N-AROILFENILALANINA, USO DOS MESMOS, MEDICAMENTOS CONTENDO OS MESMOS. |
| 摘要 |
Compounds of formula (1) as well as their salts and esters are disclosed wherein X, X', Z and Y are as described in the specification and which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4. |
| 申请公布号 |
BR9811730(B1) |
申请公布日期 |
2014.04.08 |
| 申请号 |
BR19989811730 |
申请日期 |
1998.08.13 |
| 申请人 |
F HOFFMANN LA ROCHE AG |
发明人 |
LI CHEN;ROBERT WILLIAM GUTHRIE;TAI-NANG HUANG;KENNETH G HULL;ACHYTHARAO SIDDURI;JEFFERSON WRIGHT TILLEY |
| 分类号 |
C07C233/87;A61K31/165;A61K31/198;A61K31/216;A61K31/27;A61K31/277;A61K31/33;A61K31/41;A61K31/4192;A61K31/42;A61K31/426;A61K31/437;A61K31/44;A61K31/4418;A61K31/47;A61K31/496;A61K31/505;A61K31/519;A61K31/66;A61P1/00;A61P11/06;A61P19/02;A61P25/00;A61P29/00;C07C235/52;C07C235/84;C07C237/22;C07C237/36;C07C275/42;C07C311/17;C07C311/21;C07C317/44;C07C317/50;C07C323/39;C07C323/62;C07D211/64;C07D213/82;C07D215/30;C07D215/50;C07D233/32;C07D233/36;C07D233/74;C07D233/80;C07D239/28;C07D249/06;C07D257/06;C07D261/18;C07D277/20;C07D277/56;C07D295/08;C07D295/088;C07D295/14;C07D295/15;C07D401/12;C07D413/12;C07D471/04;C07D487/04 |
主分类号 |
C07C233/87 |
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