The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paedi-atric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
申请公布号
CA2380840(C)
申请公布日期
2014.04.08
申请号
CA20002380840
申请日期
2000.07.31
申请人
SMITHKLINE BEECHAM BIOLOGICALS S.A.
发明人
BERTHET, FRANCOIS-XAVIER JACQUES;DALEMANS, WILFRIED L. J.;DENOEL, PHILIPPE;DEQUESNE, GUY;FERON, CHRISTIANE;LOBET, YVES;POOLMAN, JAN;THIRY, GEORGES;THONNARD, JOELLE;VOET, PIERRE