发明名称 |
Methods of utilizing the arrestin-2/STAM-1 complex as a therapeutic target |
摘要 |
Methods of utilizing the arrestin-2/sTAM-1 complex as a therapeutic target. The methods include treating cells of a living organism to mediate an interaction between arrestin-2 and STAM-1 adapter protein molecules, wherein the interaction is characterized by the arrestin-2 adapter protein molecule directly binding to the STAM-2 adapter protein molecule. Pharmacological agents can be identified for therapeutic uses by determining whether the pharmacological agent disrupts the interaction between the arrestin-2 and STAM-1 adapter protein molecules. |
申请公布号 |
US8691188(B2) |
申请公布日期 |
2014.04.08 |
申请号 |
US201113115666 |
申请日期 |
2011.05.25 |
申请人 |
MARCHESE ADRIANO;MALIK ROHIT;LOYOLA UNIVERSITY CHICAGO |
发明人 |
MARCHESE ADRIANO;MALIK ROHIT |
分类号 |
A61K49/00;C07H21/04;C12P19/34;C12P21/06;C12Q1/68 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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