发明名称 |
CHIMERIC NEUREGULINS AND METHOD OF MAKING AND USE THEREOF |
摘要 |
Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, Erb 3, or Erb 4 comparing to that of the first neuregulin. |
申请公布号 |
WO2014051567(A1) |
申请公布日期 |
2014.04.03 |
申请号 |
WO2012US57272 |
申请日期 |
2012.09.26 |
申请人 |
MOREHOUSE SCHOOL OF MEDICINE;FORD, BYRON, D.;LILLARD, JAMES, W. |
发明人 |
FORD, BYRON, D.;LILLARD, JAMES, W. |
分类号 |
C07K19/00;A61K38/18;A61P25/16;C07K14/475 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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