CYTOCHROME P450 MONOOXYGENASE INHIBITOR INTERMEDIATE AND PREPARATION METHOD AND USE THEREOF

摘要

Provided in the present invention are a cytochrome P450 monooxygenase inhibitor intermediate and the preparation method and the use thereof. In particular, provided in the present invention is a compound of intermediate formula IV which can be used in the preparation of cytochrome P450 monooxygenase inhibitor (Cobicistat), in the formula, X respresents bromine, chlorine, or sulfonate; R represents hydroxyl, substituted or unsubstituted C1-C8 straight chain, branched chain alkyl or cycloalkyl, substituted or unsubstituted C3-C20 aralkyl. Also provided in the present invention are the method for preparing the intermediate, and the method for preparing Cobicistat by the intermediate. The preparation process of the present invention is simple, the cost is low and it is suitable for industrial production.