发明名称 |
SILK-BASED DRUG DELIVERY SYSTEM |
摘要 |
The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crystallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer. |
申请公布号 |
US2014093580(A1) |
申请公布日期 |
2014.04.03 |
申请号 |
US201314095366 |
申请日期 |
2013.12.03 |
申请人 |
EIDGENOSSISCHES TECHNISCHE HOCHSCHULE (THE SWISS FEDERAL INSTITUTE OF TECHNOLOGY);TRUSTEES OF TUFTS COLLEGE |
发明人 |
KAPLAN DAVID L.;MEINEL LORENZ |
分类号 |
A61K47/42;A61K9/70;A61K38/17;A61K38/39;A61K47/46 |
主分类号 |
A61K47/42 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|