NOVEL PROCESS FOR PREPARATION OF AZILSARTAN MEDOXOMIL

摘要

The present invention provides novel process for preparation of azilsartan medoxomil (II) comprising coupling of azilsartan (I) and 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one (VII) in presence of carbonyl compound, R3COR4, wherein substituents R3 and R4 represent a heterocyclic ring selected from imidazole, benzimidazole, triazole; or in presence of carbodiimides and base wherein carbodiimide is selected from dicyclohexylcarbodiimide, diisopropylcarbodiimide, N-[3-(dimethyl-amino) propyl]-N'- ethylcarbodiimide. The present invention further provides novel Form I of azilsartan kamedoxomil.