The invention relates to a method of regulating neurotrophin-tyrosine kinase receptor signalling in a cell comprising modulating the interaction between the juxtamembrane region of the intracellular domain of the neurotrophin receptor p75 and Trk. The invention also relates to compositions comprising compounds which modulate the interaction between the juxtamembrane region of the intracellular domain of the neurotrophin receptor p75 and Trk, and use of the compounds and compositions for the treatment of neurotrophin-Trk signaling related diseases and disorders.
申请公布号
WO2014049556(A2)
申请公布日期
2014.04.03
申请号
WO2013IB58910
申请日期
2013.09.27
申请人
THE UNIVERSITY OF QUEENSLAND
发明人
COULSON, ELIZABETH JANE;MATUSICA, DUSAN;BREDY, TIMOTHY WILLIAM;SKELDAL, SUNE