发明名称 |
Nanoparticulate phosphate adsorbent on the basis of maghemite or maghemite/magnetite, production and uses thereof |
摘要 |
<p>The present invention relates to a phosphate adsorbent on the basis of maghemite or maghemite/magnetite comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a coating selected from monomeric carbohydrates, in particular monosaccharides or disaccharides, alditols, or mixtures thereof, and/or (iii) a pharmaceutical excipient selected from polymeric carbohydrates, wherein the phosphate adsorbent has the form of nanoparticles with a particle size of the iron oxide core (i) of less than 20 nm. The present invention further relates to a method for the production of a phosphate adsorbent on the basis of maghemite or maghemite/magnetite, to pharmaceutical compositions comprising the phosphate adsorbent, and to medical uses thereof, especially for the prevention and/or treatment of hyperphosphatemia.</p> |
申请公布号 |
AU2012306775(A2) |
申请公布日期 |
2014.04.03 |
申请号 |
AU20120306775 |
申请日期 |
2012.09.03 |
申请人 |
CHARITE - UNIVERSITATSMEDIZIN BERLIN |
发明人 |
WAGNER, SUSANNE;TAUPITZ, MATTHIAS;SCHELLENBERGER, EYK;SCHNORR, JORG;EBERT, MONIKA;GENTER, GESCHE;KRATZ, HARALD |
分类号 |
A61K33/26;A61K9/14;A61K9/51;C01G49/00;C01G49/02 |
主分类号 |
A61K33/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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