发明名称 |
METHODS FOR THE DIAGNOSIS AND TREATMENT OF SJÖGREN'S SYNDROME |
摘要 |
Described herein is the finding that patients with Sjögren's syndrome exhibit a statistically significant increase in expression of BMP6 in the salivary gland, relative to healthy control subjects. Also described herein is the finding that overexpression of BMP6 in the salivary glands of mice results in an increase in electrical potential across the salivary gland. Thus, provided herein are methods of diagnosing a subject as having Sjögren's syndrome, or at risk for developing Sjögren's syndrome, by measuring the level of BMP6 expression in a salivary gland of a subject, measuring electrical potential in a salivary gland of a subject, or both. Also provided herein are methods of treating a subject with Sjögren's syndrome by administering an agent that inhibits expression of BMP6 expression or activity. Also described herein is the use of XIST and MECP2 as diagnostic and therapeutic targets for male Sjögren's syndrome patients. |
申请公布号 |
WO2014052393(A2) |
申请公布日期 |
2014.04.03 |
申请号 |
WO2013US61587 |
申请日期 |
2013.09.25 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
CHIORINI, JOHN, A.;WELLER, MELODIE;YIN, HONGEN |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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