发明名称 |
COMPOSITIONS AND METHODS OF INHIBITING MASP-1, MASP-2 AND/OR MASP-3 FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA |
摘要 |
Provided are methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MAS P-3-depencien! complement activation. Also provided are methods and compositions for increasing the survival of red blood cells in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of at least one of a MASP-1 inhibitory agent and/or a MAS P-3 inhibitory agent effective to increase the survival of red blood cells. The subject may be administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent, administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent. |
申请公布号 |
WO2013180834(A3) |
申请公布日期 |
2014.04.03 |
申请号 |
WO2013US35488 |
申请日期 |
2013.04.05 |
申请人 |
OMEROS CORPORATION;UNIVERSITY OF LEICESTER |
发明人 |
SCHWAEBLE, HANS-WILHELM;DEMOPULOS, GREGORY, A. |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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