TREATING BLADDER TUMOR CELLS USING FIBRONECTIN ATTACHMENT PROTEIN AS A TARGET
摘要
Composition and methods are disclosed for utilizing micro-aggregation of FAP- containing complexes to promote their fast internalization. This approach allows the uptake of cytotoxic cargo coupled to either FAP-Antibodies or FAP-liposome complexes by tumor bladder cells. Importantly, this approach is efficient even under serum- free conditions such as the ones found in the lumen of the bladder.
申请公布号
WO2012065044(A3)
申请公布日期
2014.04.03
申请号
WO2011US60339
申请日期
2011.11.11
申请人
PURDUE RESEARCH FOUNDATION;AGUILAR, RUBEN, CLAUDIO;RATLIFF, TIMOTHY;THOMPSON, DAVID;CRIST, SCOTT
发明人
AGUILAR, RUBEN, CLAUDIO;RATLIFF, TIMOTHY;THOMPSON, DAVID;CRIST, SCOTT