发明名称 NOVEL COMPOUND WITH AMYLOID AFFINITY
摘要 It is intended to provide a compound that is effective as a diagnostic imaging probe that targets amyloid, and a diagnostic agent for Alzheimer's disease comprising the compound. Provided are a compound represented by the following formula (1), or a salt thereof: wherein R 1 is a radioactive halogen substituent, 0 to 2 of A 1 , A 2 , A 3 and A 4 represent N, and the rest represent CH, and a diagnostic agent for Alzheimer's disease which comprises a compound represented by the above formula (1) or a salt thereof. The present compound and the present diagnostic agent for Alzheimer's disease transfer into brain after administration, and indicate good accumulation on amyloid deposited in the brain.
申请公布号 KR20140040735(A) 申请公布日期 2014.04.03
申请号 KR20137032274 申请日期 2012.05.29
申请人 NIHON MEDI-PHYSICS CO., LTD. 发明人 OKUMURA YUKI;MAYA YOSHIFUMI;SHOYAMA YOSHINARI;ONISHI TAKAKO
分类号 C07D471/04;A61K31/437;A61P25/28 主分类号 C07D471/04
代理机构 代理人
主权项
地址